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DOI: 10.18544/PEDM-24.01.0102
Pediatr Endocrino Diabetes Metab 2018;24,1:45-51

Chemerin as an early marker of metabolic syndrome

Joanna Roguska, Agnieszka Zubkiewicz-Kucharska

Key words 

chemerin, metabolic syndrome, obesity, diabetes

Chemerin (CHEM) is a protein synthesized primarily by adiposse tissue and liver. CHEM acts both paracrine and autocrine, stimulating adipocytes maturation and differentiation. In addition to its hormonal function, CHEM acts as a chemoattractant for immune cells, regulating the innate and acquired inflammatory response. Its pleiotropic properties also affect the carbohydrates and lipids metabolism. High concentrations of CHEM are observed in people with obesity, type 2 diabetes, hypertension, and hyperlipidemia – components of the metabolic syndrome. Therefore CHEM also may be considered as an early predictive marker for diagnosing metabolic syndrome, also in adolescence and childhood. 


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DOI: 10.18544/PEDM-24.01.0102
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Pediatric Endocrinology Diabetes and Metabolism

2018; 24, 1: 1-51
2017; 23, 4: 169-222
2017; 23, 3: 117-168
2017; 23, 2: 59-116
2017; 23, 1: 1-58
2016; 22, 4: 133-180
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2015; 21, 4: 149-191
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2015; 21, 2: 51-96
2015; 21, 1: 1-50
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2014; 20, 2: 35-82